Along with bassist Stefaan Van Leuven and drummer Piet Dierickx, the group formed in the city of Ghent and released their debut album, Leave the Story Untold, on Play It Again Sam in 1996. Much Against Everyone's Advice followed in 1998, earning the group an international audience and critical acclaim. The Dewaele brothers began shifting their focus to their remix project, 2 Many DJs, named after the biggest hit from Much Against Everyone's Advice. Loosely operating under the Soulwax umbrella, they began creating clever mash-ups that they featured on their own internet station, Radio Soulwax. Numerous mixes were issued as part of the Hang All DJs and As Heard on Radio Soulwax series, and the second volume of the latter series was given an official release by PIAS. The mix took on a life of its own, earning widespread acclaim, including being named album of the year by the New York Times.
The Dewaeles continued to maintain both projects throughout the rest of the decade. Soulwax's third album, 2004's Any Minute Now, contained three U.K. Top 40 hits, and was followed by the 2005 remix album Nite Versions, pushing the group's dance influences to the forefront. 2007's Most of the Remixes... collected their mixes for LCD Soundsystem, Sugababes, Daft Punk, and many others. Part of the Weekend Never Dies, a DVD and live album, was released in 2008. Soulwax produced material for Tiga, Peaches, and Das Pop, and collaborated with Crookers and Mixhell on the 2010 single "We Love Animals."
The Radio Soulwax app was launched in 2011, showcasing the Dewaele brothers' DJ mixes. In 2013, they hosted the Soulwax FM radio station in the game Grand Theft Auto V. In 2016, they re-teamed with director Felix Van Groeningen, for whom they had previously scored the soundtrack for 2004's Steve + Sky. The new film was called Belgica and for the soundtrack, Soulwax ambitiously created 16 different fictitious bands, each with their own single relating to the film. In 2017, the group released the percussion-heavy From Deewee. The album was recorded in one take with Igor Cavalera (formerly of metal act Sepultura), Victoria Smith (formerly of Ipso Facto), and Turbowolf drummer Blake Davies on percussion. They also adopted the one-take recording session idea for its follow-up, Essential, which arrived the following year. Soulwax's remix of Marie Davidson's "Work It" became a huge club hit, and was nominated for Best Remixed Recording at the 2020 Grammy Awards. 2020's Deewee Sessions, Vol. 01 was created entirely using the legendary EMS Synthi 100 analog synthesizer and recorded over the course of a year at the University of Ghent's Institute for Psychoacoustics and Electronic Music. Soulwax released a single titled "Empty Dancefloor" at the end of the year, and remixed songs by Fontaines D.C., Chet Faker, Sylvester, and Priya Ragu in 2021. ~ Timothy Monger & Paul Simpson, Rovi