Originally from New York City, Klayton participated in several metal and industrial bands beginning in the late 1980s. Following the dissolution of his previous bands Circle of Dust, Angeldust, and Argyle Park, Klayton began recording solo material as Celldweller in 1999. Celldweller's self-titled debut album, an ambitious fusion of trance, drum'n'bass, metal, and alternative rock, appeared in 2003 on Position Music/Esion Media after four years of production and delays. The album was well received by various online music communities, and eventually every song from the album was licensed to television shows, motion pictures, or video games. The Beta Cessions, a double CD of remixes, demo versions, and instrumentals, followed in 2004.
In 2006, Klayton started the independent label FiXT Music, which would release all of his subsequent recordings, as well as releases by other artists. While working on Celldweller's second proper full-length, Wish Upon a Blackstar, Klayton began Take It and Break It, a competition in which fans could remix Celldweller songs. The competition spawned several volumes of remix collections, which were released on FiXT. Soundtrack for the Voices in My Head, Vol. 1, an instrumental album intended for further media licensing, was released in 2008. Klayton began digitally releasing tracks from Wish Upon a Blackstar in 2009 in the form of two-song "chapters." He also began recording Soundtrack for the Voices in My Head, Vol. 2, releasing the first chapter in 2010. The remix album The Complete Cellout, Vol. 1 appeared in 2011. Both Wish Upon a Blackstar and Soundtrack for the Voices in My Head, Vol. 2 finally saw full release in 2012, as well as the concert recording Live Upon a Blackstar, also released as a Blu-ray/DVD. By this time, Celldweller's sound had evolved to include elements of dubstep, and was referred to as "metalstep."
Celldweller's self-titled debut was given a tenth anniversary deluxe reissue in 2013, and Klayton began working on the next proper Celldweller album, End of an Empire, as well as Soundtrack for the Voices in My Head, Vol. 3. The first two chapters of End of an Empire, both full-length compilations with numerous remixes and instrumentals, were released in 2014, as well as the compilation Transmissions, Vol. 1. The chart-topping third chapter of End of an Empire appeared in 2015, along with Transmissions, Vol. 2. The following year, Celldweller joined with video game composer Atlas Plug for the soundtrack to Killer Instinct: Season Three, a reboot of the '90s fighting game. Space and Time (Expansion), a collection of remixes of tracks from his 2012 album, arrived that same year. Offworld, his seventh official LP, was issued in 2017. The album placed more of a focus on emotional songwriting rather than aggressive sonics, and was influenced by shoegaze and dream pop. Remixed Upon a Blackstar appeared in 2018, and studio album Satellites followed in 2019. ~ Paul Simpson, Rovi