Gabriel was born in Guamuchil, Sinaloa. She took the stage for the first time at age six, singing José Alfredo Jiménez's "Regalo a Dios," an experience the artist never forgot. The daughter of Ramon Araujo and Japanese descendant Isabel Young, Gabriel was always supported by her parents. At age 15, the enthusiastic teenager moved to Tijuana to study accounting and to pursue a singing career. She recorded her first song, "Compréndeme," in 1977. Later, she came in second place at a local festival known as Valores Juveniles (Youthful Values), after singing "No Me Lastimes Más." In 1986, Ana Gabriel represented Mexico at the OTI Festival. She had her breakthrough two years later after releasing Tierra de Nadie, which included her first smash, a song called "Simplemente Amigos."
Gabriel's many singles, including 1987's "Ay Amor," 1989's "Simplemente Amigos," 1990's "Es Demasiado Tarde" and "Quien Como Tu," 1991's "Ahora," 1992's "Evidencias," and 1997's "Con un Mismo Corazon" have attained Top Five status. During the 2000s, her albums proved even more successful than her singles. Led by chart-toppers Historia de una Reina in 2005 and the following year's La Reina Canta a Mexico, her recordings continued to sell well. During the 21st century's second decade, albums such as 2013's Un Mariachi en Altos de Chavón (and the live Altos de Chavón: El Concierto) and the following year's Mexicanísimo resonated with listeners, resulting in high chart placements. In 2015, she delivered the best-selling Ana Gabriel Interpreta a Juan Gabriel. Gabriel followed it with two live albums.
In 2017, Gabriel appeared in Bernard MacMahon's award-winning documentary celebration of North American roots music, The American Epic Sessions. She recorded Lydia Mendoza's classic corrido "Mal Hombre" on the restored first electrical sound recording system from the 1920s. Among the musicians in her backing band were pianist/producer/songwriter Van Dyke Parks and the Mars Volta's Omar-Rodriguez Lopez. In 2018, two studio offerings appeared, including the all-romanticas set Arpegios de Amor, which placed in the Top Ten at Latin Pop and Mexican Regional, as well as on streaming charts. At the end of 2020, Gabriel released Por Amor a Ustedes, a collection of classic bandas closely associated with her native Sinaloa. ~ Drago Bonacich, Rovi