Manzanera continued balancing his Roxy Music duties with solo projects and session dates, in 1975 producing the up-and-coming New Zealand group Split Enz; with Roxy Music entering a state of suspended animation a year later, he formed the short-lived 801 before touring with Ferry. The 801 aegis was revived for 1977's Listen Now; upon completing the follow-up, K-Scope, Manzanera joined the revived Roxy Music for Manifesto, their best-selling album in the U.S. He remained with the group through their last studio album, the 1982 masterpiece Avalon, and following their final tour he reunited with ex-Roxy saxophonist Andy Mackay as the Explorers, also recording a 1986 LP with onetime Asia frontman John Wetton. While 1990's Southern Cross featured extensive vocal contributions from onetime Split Enz member Tim Finn, Manzanera was largely absent from the studio during much of the decade to follow, primarily focusing on live performances (including appearances at the Guitar Legends and WOMAD festivals). In 1999, he issued the Latin-influenced Vozero, closing out the year by backing Ferry at the British Gas Millennium Concert, their first joint performance in 18 years.
In 2001, Manzanera took part in a Roxy Music reunion tour, with the group playing 52 dates around the world; shorter tours followed in 2003 and 2004. By this time, Manzanera had begun releasing archival material through his own Expression Records label, as well as new recordings, such as 2004's 6pm, 2005's 50 Minutes Later, and 2008's Firebird VII. In 2006, Manzanera co-produced and performed on Pink Floyd guitarist David Gilmour's solo album On an Island; he also appeared on Gilmour's subsequent concert release, 2008's Live in Gdansk. Between 2003 and 2008, Manzanera collaborated with artist and songwriter Lucho Brieva on a cycle of songs about a pair of ne'er-do-wells from Bogota; they named the project Corroncho, and released an album under that moniker in 2009, which included guest appearances by Robert Wyatt, Paul Thompson, Annie Lennox, and Chrissie Hynde. Poet Anna Le teamed up with Manzanera for a collaborative album, Nth Entities, that was released in 2012. Another solo album from Manzanera, The Sound of Blue, appeared in 2015, and in 2017 he and Brieva reunited to release Corroncho 2. ~ Jason Ankeny, Rovi