Greinke began composing music in 1980, while studying meteorology at Pennsylvania State University. Along with collaborator Rob Angus, Greinke moved to Seattle in 1982 and co-founded record label and production company Intrepid. The label released several cassettes by both artists, including 1984 collaboration Night and Fog, as well as Greinke's first LP, 1985's Cities in Fog. German label Dossier released 1987's Places of Motility and 1988's Timbral Planes, and Greinke contributed to numerous dark ambient, drone, and industrial compilations. In 1990, Changing Skies was released by Swedish label Multimood Records, and Greinke shared a split CD with avant-prog legends Art Zoyd and trombonist/composer J.A. Deane, released by Ear-Rational Records. The same label issued Crossing Ngoli, Greinke's 1992 CD with Angus. Lost Terrain appeared on Kim Cascone's Silent label the same year. Linden Music released 1993's In Another Place and 1994's Big Weather. The latter featured guitar playing by Dennis Rea, Greinke's bandmate in Fourth World fusion group LAND. The band's self-titled debut was released by Australian label Extreme in 1995, and they toured China in 1996, including a performance at the Beijing International Jazz Festival. LAND's second album, Archipelago, followed in 1997.
Greinke's solo album Swimming was released by Prudence in 1998. The following year, he released Hana, a self-titled full-length by his collaborative duo with Sky Cries Mary vocalist Anisa Romero. The album was one of the premier releases on First World Music, a Seattle-based label run by several notable musicians including Greinke, Trey Gunn, and Bill Rieflin (who also played in LAND). Following Greinke's 1999 solo album Ride, the label released Hana's second album, Omen, and LAND's third and final release, Road Movies, both in 2001. Dream the Red Clouds, Greinke's collaboration with darkwave duo Faith Disease, appeared in 2002, and solo album Wide View was released the same year. Weather from Another Planet was issued in 2003, followed by 2005's Soundtracks, collecting some of his film and dance pieces. Greinke moved to the Lotuspike label for 2007's Winter Light and 2009's Virga. Scenes from a Train, featuring some of Greinke's former LAND collaborators, was released by Infectious Music in 2013. Five years later, Greinke's Before Sunrise, an enchanting fusion of ambient and minimalist classical, was issued by Spotted Peccary. Other Weather appeared in 2021, followed by Noctilucent in 2022. ~ Paul Simpson, Rovi