Born in Massachusetts, Angelides grew up in Connecticut and began giving away self-released CDs of his tracks at gigs in New England, starting with 1999's Machines on Task. In 2002, drum'n'bass/nu breaks label Downbeat Productions began releasing Eskmo tracks as 12" singles. This led to singles on other breaks labels such as Cyberfunk, Vertical Sound, and Mechanoise. By 2008, Angelides had become a crucial part of the Bay Area's then-emerging dubstep scene, and his Willow Grail EP on Studio Rockers reflected this style. Following releases on Bassrock Records and his own Ancestor imprint, Eskmo appeared on Planet Mu at the end of 2009 with the single Let Them Sing. Almost immediately, he was releasing material on Warp (Hendt, with Eprom) and Ninja Tune, which issued his self-titled proper debut album in October of 2010. By this point, his productions had become far more songlike than his previous work, extensively featuring his own vocals.
Following the album, Angelides released several digital EPs and rarities collections on Ancestor, and co-founded a Los Angeles-based artist collective called the Echo Society. In 2015, he moved to RS Records' Apollo sublabel for a more ambient album titled SOL. During the same year, he also launched FeelHarmonic, an outreach program geared toward deaf students. In 2016, Angelides composed the score for the Showtime drama series Billions. Milan released Eskmo's Billions soundtrack in 2017. ~ Paul Simpson, Rovi