Protégés of the Insane Clown Posse, the Detroit-area horrorcore rap duo Twiztid base their act on a similarly theatrical, outrageous, makeup-heavy image and an obsession with serial killers, horror films, marijuana, and comic books. Comprised of Jamie Spaniolo (Jamie Madrox) and Paul Methric (Monoxide), the duo has released 15 studio albums since emerging in 1998, including career highlights like The Green Book (2003), Heartbroken Homicidal (2010), The Darkness (2015), and Unlikely Prescription (2021).

Jamie Madrox and the Monoxide Child cast themselves as psychotic axe murderers on their 1998 debut album, Mostasteless, which was reissued with new artwork and extra tracks a year later in the wake of ICP's rise to national notoriety. Twiztid's second album, Freek Show, was released on Halloween 2000 in conjunction with ICP's Bizzar/Bizaar sets; Mirror Mirror followed two years later. The Green Book hit the shelves in 2003, with Man's Myth, Vol. 1 landing in 2005. The 2007 album Independent's Day featured numerous guest stars, including DJ Quik and tha Dogg Pound along with D12 members Bizarre and Proof. Two years later, W.I.C.K.E.D. appeared, the initials standing for "Wish I Could Kill Every Day." Monoxide produced most of the cuts on their 2010 effort, Heartbroken Homicidal, and Abominationz landed in 2012 as the group's last album for ICP's Psychopathic label.

A year later, the duo issued the EP A New Nightmare on their own label. It was followed in 2015 by their tenth full-length studio album, The Darkness, with a pair of reissued remasters of Mutant, Vol. 2 and Green Book arriving in 2016. The pair's 11th set, The Continuous Evilution of Life's ?'s, arrived to the delight of Juggalos everywhere in January 2017. Peaking within the Billboard Top 30, the album featured guest appearances by familiar faces like Blaze Ya Dead Homie, the D.O.C., and Lex The Hex Master, as well as rapper G-Mo Skee. Before the end of the year, they returned with Twiztid Presents: Year of the Sword. The duo kept up a steady stream of singles, releasing the Trick or Treat EP in October 2018 before resuming their singles output in 2019 with tracks like "Somthing New" and the Young Wicked collaboration "Clockin' w's." Later that year they released Generation Nightmare, which peaked at number three on the Billboard Top Independent Albums chart. Mad Season and Revelashen appeared in 2020, and in 2021 the prolific duo entered the mainstream rock charts with the single "Rose Petal," which appeared on the full-length Unlikely Prescription later that year. ~ Steve Huey, Rovi