Rousset was born on April 12, 1961, in Avignon, France. After studying piano as a boy, he became deeply interested in the harpsichord at age 13. He studied with Huguette Dreyfus at the Schola Cantorum in Paris and, from 1980 to 1983, with Bob van Asperen at the Royal Conservatory of the Hague. He won a special certificate of distinction at the Schola Cantorum and, in 1983, the first prize at the International Harpsichord Competition in Bruges. Rousset rose quickly through the ranks of the world's harpsichordists. He soon appeared at some of the most prestigious early music festivals, including those of Aix-en-Provence, Utrecht, and Les Printemps des Arts de Nantes, among others. He recorded for the Decca label and its early music imprint L'Oiseau-Lyre, and a recording of the Piéces de clavecin of Rameau won the 1992 Gramophone Award for Best Baroque Non-Vocal Release and the Belgian Cecilia Prize. During his time as a specialist in Baroque harpsichord, he often performed the harpsichord continuo parts in ensemble music. It was natural that Rousset's harpsichord appearances with such established authentic instrument ensembles as La Petite Bande, Musica Antique de Cologne, and the Academy of Ancient Music led him to an interest in leading a Baroque ensemble, and he founded Les Talens Lyriques in 1991. The group was primarily interested in reviving French Baroque music and exploring the connections between the distinct national styles of France and other major European nations. An important introduction of Les Talens Lyriques to the wider world came in 1993 at the Festival de Beaune when the group performed Handel's opera Scipione. It has also played ballets and operas of Cimarosa, Berutti, and Mondonville and experienced popular success with the soundtrack for the movie Farinelli, which had extraordinary sales for an early music classical release, moving well over 600,000 copies worldwide.
Rousset has continued to record as a solo harpsichordist, often exploring the rich fund of French Baroque harpsichord music beyond Rameau and Couperin. The explosion of interest in Baroque opera in the 2010s has stimulated a busy schedule of performances and recordings of operas with Rousset as director; he has recorded, mostly for the Aparte and Ediciones Singulares labels, such novelties as Lully's Amadis (2014), Antonio Salieri's Les Danaïdes (2015), and, in 2017, Etienne-Nicolas Méhul's early Romantic Uthal. By that time, Rousset ranked as one of the most prolific performers of Baroque repertory on the European scene. Between 2018 and mid-2020, he released no fewer than 13 albums, mostly on Aparte, and he remained vigorously active through the COVID-19 pandemic. In 2023, he moved to the Château de Versailles label for a recording of Lully's opera Psyché. Rousset is noteworthy as a teacher and mentor, with countless "graduates" from Les Talens Lyriques populating European early music orchestras and stages. In 2004, he was honored by the French government as Officier des Arts et Lettres and Chevalier dans l'Ordre National du Mérite. ~ James Manheim & Joseph Stevenson, Rovi