Born in 1980 in Bloomington, Indiana, Keberle grew up in a musical family with a father who played trumpet and taught music and a mother who played piano and worked as a church choir director. He initially started out on piano and also learned the violin through the Suzuki Method before settling on the trombone in the fifth grade. By his teens, he was augmenting his love for horn bands like Chicago, Blood, Sweat Tears, and Tower of Power by playing along to jazz albums by John Coltrane and Dexter Gordon. He studied privately with David Matterne, the principal trombonist for the Spokane Symphony, and gained valuable early performance experience with the Spokane Youth Symphony, the Spokane Jazz Orchestra, and the Whitworth Jazz Ensemble. After high school, he double-majored in physics and music at Washington's Whitworth University before transferring to the Manhattan School of Music. There, he further honed his skill studying trombone with Steve Turre and composition with Michael Abene and Manny Albam. Following his graduation, he earned an artist diploma in Jazz Performance from Juilliard.
Based in Brooklyn, he has performed with an array of artists and ensembles, including the David Berger Jazz Orchestra, Wynton Marsalis and Jazz at Lincoln Center, and the Maria Schneider Jazz Orchestra, among others. As a leader, he made his debut in 2003 with The Ryan Keberle Double Quartet and returned with 2010's Heavy Dreaming. In 2013, he released Music Is Emotion featuring Catharsis, a pianoless quartet with trumpeter Mike Rodriguez, bassist Jorge Roeder, and drummer Eric Doob. Along with touring as a member of singer/songwriter Sufjan Stevens' group, he has worked with such wide-ranging performers as Ivan Lins, David Bowie, Alicia Keys, and David Byrne.
In 2014, Keberle released his second album with Catharsis, Into the Zone, on Dave Douglas' Greenleaf Music. It found him expanding the lineup with Chilean vocalist/guitarist Camila Meza. Meza was also on board for 2016's Azul Infinito, an album inspired by the trombonist's work with South American composers including Ivan Lins, Sebastian Cruz, and Samuel Torres. A third Catharsis album, Find the Common, Shine a Light, arrived the following year and found Keberle ruminating on the political turmoil in the United States. Around the same time, he formed the international chamber jazz ensemble Reverso with French pianist Frank Woeste and French cellist Vincent Courtois. In 2019, he was back with Catharsis for another political-minded production, The Hope I Hold, whose title was inspired by a line from Langston Hughes' poem "Let America be America Again." Building upon a 2017 trip to São Paulo, Brazil, he formed Ryan Keberle's Collectiv do Brasil with pianist Felipe Silveira, bassist Thiago Alves, and drummer Paulinho Vicente. Drawing upon their shared love of Brazilian artists like Toninho Horta and Milton Nascimento, they released Sonhos da Esquina in 2022. ~ Matt Collar, Rovi